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Purpose

Our aim was to investigate the pertinence of diffusion and perfusion magnetic resonance imaging (MRI) parameters obtained at 17.2 T in a 9L glioma rat brain tumor model to evaluate tumor tissue characteristics.

Materials and Methods

The local animal ethics advisory committee approved this study. 9L glioma cells were injected intracerebrally to 14 Fischer rats. The animals were imaged at 7 or 12 days after implantation on a 17.2-T MRI scanner, using 72 different b values (2–3025 s/mm 2). The signal attenuation, S/So, was fitted using a kurtosis diffusion model (ADCo and K) and a biexponential diffusion model (fractions f fast and f slow and diffusion coefficients D fast and D slow) using b values greater than 300 s/mm 2. To bridge the 2 models, an average diffusion coefficient< D> and a biexponential index were estimated from the biexponential model as ADCo and K equivalents, respectively. Intravoxel …