作者
Mami Iima, Tomomi Nobashi, Hirohiko Imai, Sho Koyasu, Tsuneo Saga, Yuji Nakamoto, Masako Kataoka, Akira Yamamoto, Tetsuya Matsuda, Kaori Togashi
发表日期
2018/1
期刊
Acta radiologica open
卷号
7
期号
1
页码范围
2058460117751565
出版商
SAGE Publications
简介
Background
Perfusion-related intravoxel incoherent motion (IVIM) and non-Gaussian diffusion magnetic resonance (MR) parameters are becoming important biomarkers for differentiating malignant from benign tumors without contrast agents. However, diffusion-time dependence has rarely been investigated in tumors.
Purpose
To investigate the relationship between diffusion time and diffusion parameters in breast cancer and hepatocellular carcinoma xenograft mouse models.
Material and Methods
Diffusion-weighted MR images (DWI) were obtained on a 7-T magnetic resonance imaging (MRI) scanner at two different diffusion times (9.6 ms and 27.6 ms) in human breast cancer (MDA-MB-231) and hepatocellular carcinoma (HepG2 and PLC/PRF/5) xenograft mouse models. Perfusion-related IVIM (fIVIM and D*) and non-Gaussian diffusion (ADC0 and K) parameters were estimated. Parametric maps of diffusion …
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M Iima, T Nobashi, H Imai, S Koyasu, T Saga… - Acta radiologica open, 2018