作者
Ji Eun Kim, Sejong Chun, Dong Hyun Sinn, Nam Joong Kim, Semi Kim, Wonseok Kang, Jong Man Kim, Gyu‐Seong Choi, Jae‐Won Joh, Duck Cho
发表日期
2021/6
期刊
Journal of Clinical Apheresis
卷号
36
期号
3
页码范围
379-389
出版商
John Wiley & Sons, Inc.
简介
Background/Aims
High‐volume plasma exchange (HVPE), defined as an exchange of 8 to 12 L per day per procedure or 15% of the ideal body weight with fresh frozen plasma, has shown promising results in improving the survival of patients with acute liver failure (ALF). However, clinical evidence is limited. The aim of this study was to report our initial experience using HVPE as a bridge treatment in patients with ALF.
Methods
We retrospectively reviewed 32 consecutive patients awaiting liver transplantation (LT) due to ALF between 2013 and 2020 at Samsung Medical Center in Korea. HVPE has been used for patients with ALF since May 2016 at our institution.
Results
During the study period, 16 patients received HVPE. After HVPE, coagulopathies (INR, 4.46 [2.32‐6.02] vs 1.48 [1.33‐1.76], P < .05), total bilirubin (22.6 [9.1‐26.4] vs 8.9 [5.6‐11.3], P < .05), alanine aminotransferase (506 [341‐1963] vs …
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JE Kim, S Chun, DH Sinn, NJ Kim, S Kim, W Kang… - Journal of Clinical Apheresis, 2021