作者
Riikka SK Takala, Jussi P Posti, Hilkka Runtti, Virginia F Newcombe, Joanne Outtrim, Ari J Katila, Janek Frantzén, Henna Ala-Seppälä, Anna Kyllönen, Henna-Riikka Maanpää, Jussi Tallus, Md Iftakher Hossain, Jonathan P Coles, Peter Hutchinson, Mark Van Gils, David K Menon, Olli Tenovuo
发表日期
2016/3/1
期刊
World neurosurgery
卷号
87
页码范围
8-20
出版商
Elsevier
简介
Objective
Biomarkers ubiquitin C-terminal hydrolase-L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) may help detect brain injury, assess its severity, and improve outcome prediction. This study aimed to evaluate the prognostic value of these biomarkers during the first days after brain injury.
Methods
Serum UCH-L1 and GFAP were measured in 324 patients with traumatic brain injury (TBI) enrolled in a prospective study. The outcome was assessed using the Glasgow Outcome Scale (GOS) or the extended version, Glasgow Outcome Scale–Extended (GOSE).
Results
Patients with full recovery had lower UCH-L1 concentrations on the second day and patients with favorable outcome had lower UCH-L1 concentrations during the first 2 days compared with patients with incomplete recovery and unfavorable outcome. Patients with full recovery and favorable outcome had significantly lower GFAP concentrations in …
学术搜索中的文章
RSK Takala, JP Posti, H Runtti, VF Newcombe… - World neurosurgery, 2016