作者
Yingjie Chen, Mathilde André, K Adhikari, M Blin, B Bonfante, J Mendoza‐Revilla, M Fuentes‐Guajardo, S Palmal, JC Chacón‐Duque, M Hurtado, V Villegas, V Granja, C Jaramillo, W Arias, RB Lozano, P Everardo‐Martínez, J Gómez‐Valdés, H Villamil‐Ramírez, CCS de Cerqueira, T Hünemeier, V Ramallo, R Gonzalez‐José, L Schüler‐Faccini, M‐C Bortolini, V Acuña‐Alonzo, S Canizales‐Quinteros, C Gallo, G Poletti, G Bedoya, F Rothhammer, D Balding, DJ Tobin, S Wang, P Faux, A Ruiz‐Linares
发表日期
2021/11/1
期刊
British Journal of Dermatology
卷号
185
期号
5
页码范围
988-998
出版商
Blackwell Publishing Ltd
简介
Background
Genome‐wide association studies (GWASs) have identified genes influencing skin ageing and mole count in Europeans, but little is known about the relevance of these (or other genes) in non‐Europeans.
Objectives
To conduct a GWAS for facial skin ageing and mole count in adults < 40 years old, of mixed European, Native American and African ancestry, recruited in Latin America.
Methods
Skin ageing and mole count scores were obtained from facial photographs of over 6000 individuals. After quality control checks, three wrinkling traits and mole count were retained for genetic analyses. DNA samples were genotyped with Illumina’s HumanOmniExpress chip. Association testing was performed on around 8 703 729 single‐nucleotide polymorphisms (SNPs) across the autosomal genome.
Results
Genome‐wide …
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