作者
Miguel Del Campo, Ian ML Feitosa, Erlane M Ribeiro, Dafne DG Horovitz, André LS Pessoa, Giovanny VA França, Alfredo García‐Alix, Maria JR Doriqui, Hector YC Wanderley, Maria VT Sanseverino, João ICF Neri, João M Pina‐Neto, Emerson S Santos, Islane Verçosa, Mirlene CSP Cernach, Paula FV Medeiros, Saile C Kerbage, André A Silva, Vanessa van der Linden, Celina MT Martelli, Marli T Cordeiro, Rafael Dhalia, Fernanda SL Vianna, Cesar G Victora, Denise P Cavalcanti, Lavinia Schuler‐Faccini, Zika Embryopathy Task Force—Brazilian Society of Medical Genetics ZETF‐SBGM
发表日期
2017/4
期刊
American Journal of Medical Genetics Part A
卷号
173
期号
4
页码范围
841-857
简介
In October 2015, Zika virus (ZIKV) outbreak the Brazilian Ministry of Health (MoH). In response, the Brazilian Society of Medical Genetics established a task force (SBGM‐ZETF) to study the phenotype of infants born with microcephaly due to ZIKV congenital infection and delineate the phenotypic spectrum of this newly recognized teratogen. This study was based on the clinical evaluation and neuroimaging of 83 infants born during the period from July, 2015 to March, 2016 and registered by the SBGM‐ZETF. All 83 infants had significant findings on neuroimaging consistent with ZIKV congenital infection and 12 had confirmed ZIKV IgM in CSF. A recognizable phenotype of microcephaly, anomalies of the shape of skull and redundancy of the scalp consistent with the Fetal Brain Disruption Sequence (FBDS) was present in 70% of infants, but was most often subtle. In addition, features consistent with fetal immobility …
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M Del Campo, IML Feitosa, EM Ribeiro, DDG Horovitz… - American Journal of Medical Genetics Part A, 2017