作者
Laura M Paulin, Amanda J Gassett, Neil E Alexis, Kipruto Kirwa, Richard E Kanner, Stephen Peters, Jerry A Krishnan, Robert Paine, Mark Dransfield, Prescott G Woodruff, Christopher B Cooper, R Graham Barr, Alejandro P Comellas, Cheryl S Pirozzi, MeiLan Han, Eric A Hoffman, Fernando J Martinez, Han Woo, Roger D Peng, Ashraf Fawzy, Nirupama Putcha, Patrick N Breysse, Joel D Kaufman, Nadia N Hansel
发表日期
2020/1/1
期刊
JAMA internal medicine
卷号
180
期号
1
页码范围
106-115
出版商
American Medical Association
简介
Importance
Few studies have investigated the association of long-term ambient ozone exposures with respiratory morbidity among individuals with a heavy smoking history.
Objective
To investigate the association of historical ozone exposure with risk of chronic obstructive pulmonary disease (COPD), computed tomography (CT) scan measures of respiratory disease, patient-reported outcomes, disease severity, and exacerbations in smokers with or at risk for COPD.
Design, Setting, and Participants
This multicenter cross-sectional study, conducted from November 1, 2010, to July 31, 2018, obtained data from the Air Pollution Study, an ancillary study of SPIROMICS (Subpopulations and Intermediate Outcome Measures in COPD Study). Data analyzed were from participants enrolled at 7 (New York City, New York; Baltimore, Maryland; Los Angeles, California; Ann Arbor, Michigan; San Francisco, California; Salt Lake …
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LM Paulin, AJ Gassett, NE Alexis, K Kirwa, RE Kanner… - JAMA internal medicine, 2020