作者
Laura M Paulin, Benjamin M Smith, Abby Koch, MeiLan Han, Eric A Hoffman, Carlos Martinez, Chinedu Ejike, Paul D Blanc, Jennifer Rous, R Graham Barr, Stephen P Peters, Robert Paine III, Cheryl Pirozzi, Christopher B Cooper, Mark T Dransfield, Alejandro P Comellas, Richard E Kanner, M Brad Drummond, Nirupama Putcha, Nadia N Hansel
发表日期
2018/12
期刊
Annals of the American Thoracic Society
卷号
15
期号
12
页码范围
1411-1419
出版商
American Thoracic Society
简介
Rationale: Quantitative computed tomographic (CT) imaging can aid in chronic obstructive pulmonary disease (COPD) phenotyping. Few studies have identified whether occupational exposures are associated with distinct CT imaging characteristics.
Objectives: To examine the association between occupational exposures and CT-measured patterns of disease in the SPIROMICS (Subpopulations and Intermediate Outcome Measures in COPD Study).
Methods: Participants underwent whole-lung multidetector helical CT at full inspiration and expiration. The association between occupational exposures (self-report of exposure to vapors, gas, dust, or fumes [VGDF] at the longest job) and CT metrics of emphysema (percentage of total voxels < −950 Hounsfield units at total lung capacity), large airways (wall area percent [WAP] and square-root wall area of a single hypothetical airway with an internal perimeter of 10 …
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LM Paulin, BM Smith, A Koch, ML Han, EA Hoffman… - Annals of the American Thoracic Society, 2018