作者
Amany F Elbehairy, Azmy Faisal, Hannah McIsaac, Nicolle J Domnik, Kathryn M Milne, Matthew D James, J Alberto Neder, Denis E O'Donnell
发表日期
2021/3/1
期刊
European Respiratory Journal
卷号
57
期号
3
出版商
European Respiratory Society
简介
Many patients with severe chronic obstructive pulmonary disease (COPD) report an unpleasant respiratory sensation at rest, which is further amplified by adoption of a supine position (orthopnoea). The mechanisms of this acute symptomatic deterioration are poorly understood.
Sixteen patients with advanced COPD and a history of orthopnoea and 16 age- and sex-matched healthy controls underwent pulmonary function tests (PFTs) and detailed sensory–mechanical measurements including inspiratory neural drive (IND) assessed by diaphragm electromyography (EMGdi), oesophageal pressure (Pes) and gastric pressure (Pga), in both sitting and supine positions.
Patients had severe airflow obstruction (forced expiratory volume in 1 s (FEV1): 40±18% pred) and lung hyperinflation. Regardless of the position, patients had lower inspiratory capacity (IC) and higher IND for a given tidal volume (VT) (i.e. greater …
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AF Elbehairy, A Faisal, H McIsaac, NJ Domnik… - European Respiratory Journal, 2021
