作者
Nicolle J Domnik, Devin B Phillips, Matthew D James, Grace A Ayoo, Sarah M Taylor, Robin E Scheeren, Amanda T Di Luch, Kathryn M Milne, Sandra G Vincent, Amany F Elbehairy, Sophie J Crinion, Helen S Driver, J Alberto Neder, Denis E O’Donnell
发表日期
2022/3
期刊
European Journal of Applied Physiology
卷号
122
期号
3
页码范围
663-676
出版商
Springer Berlin Heidelberg
简介
Purpose
To assess whether night-time increases in mechanical loading negatively impact respiratory muscle function in COPD and whether compensatory increases in inspiratory neural drive (IND) are adequate to stabilize ventilatory output and arterial oxygen saturation, especially during sleep when wakefulness drive is withdrawn.
Methods
21 patients with moderate-to-severe COPD and 20 age-/sex-matched healthy controls (CTRL) participated in a prospective, cross-sectional, one-night study to assess the impact of COPD on serial awake, supine inspiratory capacity (IC) measurements and continuous dynamic respiratory muscle function (esophageal manometry) and IND (diaphragm electromyography, EMGdi) in supine sleep.
Results
Supine inspiratory effort and EMGdi were consistently twice as high in COPD versus CTRL (p …
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