作者
Yvonne C Lee, Clifton O Bingham III, Robert R Edwards, Wendy Marder, Kristine Phillips, Marcy B Bolster, Daniel J Clauw, Larry W Moreland, Bing Lu, Alyssa Wohlfahrt, Zhi Zhang, Tuhina Neogi
发表日期
2018/2
期刊
Arthritis care & research
卷号
70
期号
2
页码范围
197-204
简介
Objective
Pain sensitization may contribute to pain severity in rheumatoid arthritis (RA), impacting disease activity assessment. We examined whether pain processing mechanisms were associated with disease activity among RA patients with active disease.
Methods
The study included 139 subjects enrolled in the Central Pain in Rheumatoid Arthritis cohort. Subjects underwent quantitative sensory testing (QST), including assessment of pressure pain thresholds (PPTs) at multiple sites, conditioned pain modulation, and temporal summation. RA disease activity was assessed using the Clinical Disease Activity Index (CDAI) and its components. We examined cross‐sectional associations between QST measures and disease activity using linear regression.
Results
Low PPTs (high pain sensitization) at all sites were associated with high CDAI scores (P ≤ 0.03) and tender joint counts (P ≤ 0.002). Associations …
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