作者
Yong Tao, Jue Ruan, Shiou-Hwei Yeh, Xuemei Lu, Yu Wang, Weiwei Zhai, Jun Cai, Shaoping Ling, Qiang Gong, Zecheng Chong, Zhengzhong Qu, Qianqian Li, Jiang Liu, Jin Yang, Caihong Zheng, Changqing Zeng, Hurng-Yi Wang, Jing Zhang, Sheng-Han Wang, Lingtong Hao, Lili Dong, Wenjie Li, Min Sun, Wei Zou, Caixia Yu, Chaohua Li, Guojing Liu, Lan Jiang, Jin Xu, Huanwei Huang, Chunyan Li, Shuangli Mi, Bing Zhang, Baoxian Chen, Wenming Zhao, Songnian Hu, Shi-Mei Zhuang, Yang Shen, Suhua Shi, Christopher Brown, Kevin P White, Ding-Shinn Chen, Pei-Jer Chen, Chung-I Wu
发表日期
2011/7/19
期刊
Proceedings of the National Academy of Sciences
卷号
108
期号
29
页码范围
12042
出版商
National Acad Sciences
简介
We present the analysis of the evolution of tumors in a case of hepatocellular carcinoma. This case is particularly informative about cancer growth dynamics and the underlying driving mutations. We sampled nine different sections from three tumors and seven more sections from the adjacent nontumor tissues. Selected sections were subjected to exon as well as whole-genome sequencing. Putative somatic mutations were then individually validated across all 9 tumor and 7 nontumor sections. Among the mutations validated, 24 were amino acid changes; in addition, 22 large indels/copy number variants (>1 Mb) were detected. These somatic mutations define four evolutionary lineages among tumor cells. Separate evolution and expansion of these lineages were recent and rapid, each apparently having only one lineage-specific protein-coding mutation. Hence, by using a cell-population genetic definition, this …
学术搜索中的文章
Y Tao, J Ruan, SH Yeh, X Lu, Y Wang, W Zhai, J Cai… - Proceedings of the National Academy of Sciences, 2011