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macedo a.f., alves c., craveiro n. & marques f.b. (2011) Journal of Nursing Management 19, 395–399
Multiple drug exposure as a risk factor for the seriousness of adverse drug reactions

Aim  The aim of the present study was to validate the hypothesis that multiple drug exposure is an independent risk factor for serious adverse drug reactions (ADRs).

Background  Adverse drug reactions (ADRs) are an important cause of iatrogenic disease, the majority being preventable. Multiple drug exposure, ageing and female gender have been identified as important risk factors for an increased incidence of ADRs.

Method  ADR reports received by the central Portugal Regional Pharmacovigilance Unit, between January 2001 and December 2009, were studied.

Results  Nearly half (47.4%) of ADRs reports were considered serious, from which 66.7% reported multiple drug exposure (mean 3.07 ± 2.2; maximum 13 …