作者
Carlos Alves, Ana Penedones, Diogo Mendes, Francisco Batel Marques
发表日期
2016/8
来源
Acta ophthalmologica
卷号
94
期号
5
页码范围
e251-e259
简介
Purpose
Several pharmacoepidemiologic studies have been carried out evaluating the risk of retinal detachment associated with systemic fluoroquinolones. This meta‐analysis aims to investigate such association, in the light of the best scientific evidence available.
Methods
A literature search was conducted to identify relevant studies evaluating the risk for retinal detachment associated with systemic fluoroquinolones. A meta‐analysis was performed to pool rate ratios (RRs). Meta‐regressions were conducted aiming to evaluate the influence of time interval between fluoroquinolones use and retinal detachment diagnosis or treatment risk estimates.
Results
Ten observational studies from seven publications were included. Overall, fluoroquinolones were not associated with an increased risk for retinal detachment [RR 1.47 (95% CI 0.95–2.27): p = 0.09; I2 = 92.8%]. When the analysis was stratified according to …
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