作者
Felix M Weidner, Nensi Ikonomi, Silke D Werle, Julian D Schwab, Hans A Kestler
发表日期
2024/1/1
期刊
Bioinformatics
卷号
40
期号
1
页码范围
btae007
出版商
Oxford University Press
简介
Motivation
Boolean networks can serve as straightforward models for understanding processes such as gene regulation, and employing logical rules. These rules can either be derived from existing literature or by data-driven approaches. However, in the context of large networks, the exhaustive search for intervention targets becomes challenging due to the exponential expansion of a Boolean network’s state space and the multitude of potential target candidates, along with their various combinations. Instead, we can employ the logical rules and resultant interaction graph as a means to identify targets of specific interest within larger-scale models. This approach not only facilitates the screening process but also serves as a preliminary filtering step, enabling the focused investigation of candidates that hold promise for more profound dynamic analysis. However, applying this method requires a …
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