作者
Ali Al-Samydai, Moath Al Qaraleh, Khaldun M Al Azzam, Amal Mayyas, Hamdi Nsairat, Maha N Abu Hajleh, Lidia K Al-Halaseh, Nehaya Al-Karablieh, Amal Akour, Fatima Alshaik, Walhan Alshaer
发表日期
2023/6/1
期刊
Heliyon
卷号
9
期号
6
出版商
Elsevier
简介
Cancer is considered one of the top global causes of death. Natural products have been used in oncology medicine either in crude form or by utilizing isolated secondary metabolites. Biologically active phytomolecules such as gallic acid and quercetin have confirmed antioxidant, anti-bacterial, and neoplastic properties. There is an agreement that microorganisms could mediate oncogenesis or alter the immune system. This research project aims to develop a novel formulation of co-loaded gallic acid and quercetin into nanoliposomes and investigate the efficacy of the free and combined agents against multiple cancerous cell lines and bacterial strains. Thin-film hydration technique was adopted to synthesize the nanocarriers. Particle characteristics were measured using a Zetasizer. The morphology of nanoliposomes was examined by scanning electron microscopy, Encapsulation efficiency and drug loading were …
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