作者
Elsbeth Steenland, Jan Leer, Hans van Houwelingen, Wendy J Post, Wilbert B van den Hout, Job Kievit, Hanneke de Haes, Hendrik Martijn, Bing Oei, Ernest Vonk, Elzbieta van der Steen-Banasik, Ruud GJ Wiggenraad, Jaap Hoogenhout, Carla Wárlám-Rodenhuis, Geertjan van Tienhoven, Rinus Wanders, Jacqueline Pomp, M Van Reijn, Thijs van Mierlo, Ewald Rutten
发表日期
1999/8/1
期刊
Radiotherapy and Oncology
卷号
52
期号
2
页码范围
101-109
出版商
Elsevier
简介
Purpose
To answer the question whether a single fraction of radiotherapy that is considered more convenient to the patient is as effective as a dose of multiple fractions for palliation of painful bone metastases.
Patients
1171 patients were randomised to receive either 8Gy×1 (n=585) or 4Gy×6 (n=586). The primary tumour was in the breast in 39% of the patients, in the prostate in 23%, in the lung in 25% and in other locations in 13%. Bone metastases were located in the spine (30%), pelvis (36%), femur (10%), ribs (8%), humerus (6%) and other sites (10%).
Method
Questionnaires were mailed to collect information on pain, analgesics consumption, quality of life and side effects during treatment. The main endpoint was pain measured on a pain scale from 0 (no pain at all) to 10 (worst imaginable pain). Costs per treatment schedule were estimated.
Results
On average, patients participated in the study for 4 months …
引用总数
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E Steenland, J Leer, H van Houwelingen, WJ Post… - Radiotherapy and Oncology, 1999