作者
Claus Schwechheimer, Giovanna Serino, Xing-Wang Deng
发表日期
2002/10/1
期刊
The Plant Cell
卷号
14
期号
10
页码范围
2553-2563
出版商
American Society of Plant Biologists
简介
The COP9 signalosome (CSN) is an evolutionarily conserved multiprotein complex that mediates the repression of photomorphogenesis in the dark in Arabidopsis through the degradation of transcription factors such as HY5 and HYH. CSN-mediated HY5 and HYH degradation also requires the activity of the putative E3 ubiquitin ligase (E3) component COP1 and the E2-conjugating enzyme variant COP10. Recently, it was shown that CSN also is required for auxin responses mediated by the SCF-type E3 SCFTIR1. To determine whether Arabidopsis CSN is required for E3-mediated processes in a more general manner, we generated plants with reduced E3 function by suppressing AtRBX1, an essential core subunit of SCF-type E3s. We observed that AtRBX1 transgenic plants share multiple phenotypes with CSN reduced-function plants, such as morphological defects and reduced responses to auxin …
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C Schwechheimer, G Serino, XW Deng - The Plant Cell, 2002