作者
Hironori Uzuka, Yasuharu Matsumoto, Kensuke Nishimiya, Kazuma Ohyama, Hideaki Suzuki, Hirokazu Amamizu, Susumu Morosawa, Michinori Hirano, Tomohiko Shindo, Yoku Kikuchi, Kiyotaka Hao, Takashi Shiroto, Kenta Ito, Jun Takahashi, Koji Fukuda, Satoshi Miyata, Yoshihito Funaki, Hatsue Ishibashi-Ueda, Satoshi Yasuda, Hiroaki Shimokawa
发表日期
2017/10
期刊
Arteriosclerosis, Thrombosis, and Vascular Biology
卷号
37
期号
10
页码范围
1869-1880
出版商
Lippincott Williams & Wilkins
简介
Objective
Drug-eluting stent–induced coronary hyperconstricting responses remain an important issue. The adventitia harbors a variety of components that potently modulate vascular tone, including sympathetic nerve fibers (SNF) and vasa vasorum. Catheter-based renal denervation (RDN) inhibits sympathetic nerve activity. We, thus, examined whether RDN suppresses drug-eluting stent–induced coronary hyperconstricting responses, and if so, what mechanisms are involved.
Approach and Results
Protocol 1: pigs implanted with everolimus-eluting stents into the left coronary arteries underwent coronary angiography at 1 month after implantation for assessment of coronary vasomotion and adventitial SNF formation. Drug-eluting stent–induced coronary hyperconstricting responses were significantly enhanced associated with enhanced coronary adventitial SNF and vasa vasorum formation. Protocol 2: pigs …
学术搜索中的文章
H Uzuka, Y Matsumoto, K Nishimiya, K Ohyama… - Arteriosclerosis, Thrombosis, and Vascular Biology, 2017