作者
Jun Sugisawa, Yasuharu Matsumoto, Masashi Takeuchi, Akira Suda, Satoshi Tsuchiya, Kazuma Ohyama, Kensuke Nishimiya, Mina Akizuki, Koichi Sato, Shoko Ohura, Hideki Ota, Shohei Ikeda, Tomohiko Shindo, Yoku Kikuchi, Kiyotaka Hao, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Yasuhiko Sakata, Kei Takase, Masahiro Kohzuki, Hiroaki Shimokawa
发表日期
2021/4/1
期刊
International Journal of Cardiology
卷号
328
页码范围
14-21
出版商
Elsevier
简介
Aims
In vasospastic angina (VSA), coronary vasomotion abnormalities could develop not only in epicardial coronary arteries but also in coronary microvessels, where calcium channel blockers (CCBs) have limited efficacy. However, efficacy of exercise training for VSA remains to be elucidated. We thus aimed to examine whether vasodilator capacity of coronary microvessels is impaired in VSA patients, and if so, whether exercise exerts beneficial effects on the top of CCBs.
Methods
We performed 2 clinical protocols. In the protocol 1, we measured myocardial blood flow (MBF) using adenosine-stress dynamic computed tomography perfusion (CTP) in 38 consecutive VSA patients and 17 non-VSA controls. In the protocol 2, we conducted randomized controlled trial, where 20 VSA patients were randomly assigned to either 3-month exercise training group (Exercise group) or Non-Exercise group (n= 10 each).
Results
In …
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J Sugisawa, Y Matsumoto, M Takeuchi, A Suda… - International Journal of Cardiology, 2021