作者
Kota Nakamura, Goretti Hernández, Geeta G Sharma, Yuma Wada, Jasjit K Banwait, Natalia González, Jose Perea, Francesc Balaguer, Hiroyuki Takamaru, Yutaka Saito, Yuji Toiyama, Yasuhiro Kodera, C Richard Boland, Luis Bujanda, Enrique Quintero, Ajay Goel
发表日期
2022/11/1
期刊
Gastroenterology
卷号
163
期号
5
页码范围
1242-1251. e2
出版商
WB Saunders
简介
Background & Aims
Early-onset colorectal cancer (EOCRC) is a distinct clinical and molecular entity with poor survival outcomes compared with late-onset CRC. Although the incidence of EOCRC is rising, current CRC screening strategies have several limitations in diagnostic performance for EOCRC. In view of this clinical challenge, novel and robust biomarkers for detection of EOCRC are necessary. The aim of this study was to develop a circulating micro RNA (miRNA) signature for the diagnosis of patients with EOCRC.
Methods
A systematic discovery approach by analyzing a large, publicly available, noncoding RNA expression profiling dataset (GSE115513) was used. A panel of miRNAs was identified, which was subsequently validated in blood samples from patients with EOCRC in 2 independent cohorts (n = 149) compared with controls (n = 110) and pre/postoperative plasma specimens (n = 22) using …
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K Nakamura, G Hernández, GG Sharma, Y Wada… - Gastroenterology, 2022