作者
Diane M Simeone, Baoan Ji, Mousumi Banerjee, Thiruvengadam Arumugam, Dawei Li, Michelle A Anderson, Ann Marie Bamberger, Joel Greenson, Randal E Brand, ViJaya Ramachandran, Craig D Logsdon
发表日期
2007/5/1
期刊
Pancreas
卷号
34
期号
4
页码范围
436-443
出版商
LWW
简介
Objectives:
Serum biomarkers for early diagnosis of pancreatic adenocarcinoma are not currently available. We recently observed elevated expression of CEACAM1 in pancreatic adenocarcinomas and sought to determine whether serum CEACAM1 levels were elevated in pancreatic cancer patients.
Methods:
CEACAM1 messenger RNA levels were measured in pancreatic tissue samples using quantitative reverse transcription-polymerase chain reaction. CEACAM1 was localized by immunohistochemistry in adenocarcinomas and in pancreatic intraductal neoplasia lesions. CEACAM1 serum levels were assessed by a double determinant enzyme-linked immunosorbent assay and compared with serum levels of CA19-9.
Results:
CEACAM1 had higher expression levels in pancreatic adenocarcinomas compared with noncancerous pancreas (P< 0.0001) and was localized to neoplastic cells (95%(45/47) of …
引用总数
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DM Simeone, B Ji, M Banerjee, T Arumugam, D Li… - Pancreas, 2007