作者
Luis Castelo-Branco, Elif Uygur Kucukseymen, Dante Duarte, Mirret M El-Hagrassy, Camila Bonin Pinto, Muhammed Enes Gunduz, Alejandra Cardenas-Rojas, Kevin Pacheco-Barrios, Yiling Yang, Paola Gonzalez-Mego, Anayali Estudillo-Guerra, Ludmilla Candido-Santos, Ines Mesia-Toledo, Haley Rafferty, Wolnei Caumo, Felipe Fregni
发表日期
2019/10/1
期刊
BMJ open
卷号
9
期号
10
页码范围
e032710
出版商
British Medical Journal Publishing Group
简介
Introduction
Fibromyalgia (FM) is a common debilitating condition with limited therapeutic options. Medications have low efficacy and are often associated with adverse effects. Given that FM is associated with a defective endogenous pain control system and central sensitisation, combining interventions such as transcranial direct current stimulation (tDCS) and aerobic exercise (AE) to modulate pain-processing circuits may enhance pain control.
Methods and analysis
A prospective, randomised (1:1:1:1), placebo-controlled, double-blind, factorial clinical trial will test the hypothesis that optimised tDCS (16 anodal tDCS sessions combined with AE) can restore of the pain endogenous control system. Participants with FM (n=148) will undergo a conditioning exercise period and be randomly allocated to one of four groups: (1) active tDCS and AE, (2) sham tDCS and AE, (3) active tDCS and non-aerobic exercise (nAE) or …
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L Castelo-Branco, EU Kucukseymen, D Duarte… - BMJ open, 2019