作者
Dong Hwan Dennis Kim, Lakshmi Sriharsha, Wei Xu, Suzanne Kamel-Reid, Xiangdong Liu, Katherine Siminovitch, Hans A Messner, Jeffrey H Lipton
发表日期
2009/7/15
期刊
Clinical cancer research
卷号
15
期号
14
页码范围
4750-4758
出版商
American Association for Cancer Research
简介
Purpose: Imatinib resistance is major cause of imatinib mesylate (IM) treatment failure in chronic myeloid leukemia (CML) patients. Several cellular and genetic mechanisms of imatinib resistance have been proposed, including amplification and overexpression of the BCR/ABL gene, the tyrosine kinase domain point mutations, and MDR1 gene overexpression.
Experimental Design: We investigated the impact of 16 single nucleotide polymorphisms (SNP) in five genes potentially associated with pharmacogenetics of IM, namely ABCB1, multidrug resistance 1; ABCG2, breast-cancer resistance protein; CYP3A5, cytochrome P450-3A5; SLC22A1, human organic cation transporter 1; and AGP, α1-acid glycoprotein. The DNAs from peripheral blood samples in 229 patients were genotyped.
Results: The GG genotype in ABCG2 (rs2231137), AA genotype in CYP3A5 (rs776746), and …
引用总数
学术搜索中的文章
DH Kim, L Sriharsha, W Xu, S Kamel-Reid, X Liu… - Clinical cancer research, 2009