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Diffuse large B‐cell lymphoma (DLCL) exhibits heterogeneous clinical features and varies markedly in response to treatment and prognosis. Because apoptosis‐related proteins may play an important role in predicting the prognosis of DLCL, the current study investigated the prognostic significance of a high level of bcl‐2, bax, and p53 expression in relation to clinical characteristics in patients with DLCL. Paraffin‐embedded specimens from 94 patients with de novo DLCL were analyzed immunohistochemically for bcl‐2, bax, and p53 gene expression. Cases with a positive immunohistological stain in more than 50% of the tumor cells were considered to have DLCL‐positive expression. Patients were treated optimally, i.e., with radiotherapy including brief cycles of CHOP or CHOP‐like regimens for patients with stage 1–2A diseases and with at least 6 cycles of CHOP or CHOP‐like regimens for stage 2B–4 …