作者
C Arnoud Meijer, Theo Stijnen, Martin NJM Wasser, Jaap F Hamming, J Hajo van Bockel, Jan HN Lindeman
发表日期
2013/12/17
期刊
Annals of internal medicine
卷号
159
期号
12
页码范围
815-823
出版商
American College of Physicians
简介
Background
Doxycycline inhibits formation and progression of abdominal aortic aneurysms (AAAs) in preclinical models of the disease, but it is unclear whether and how this observation translates to humans.
Objective
To test whether doxycycline inhibits AAA progression in humans.
Design
Randomized, placebo-controlled, double-blind trial. (Dutch Trial Registry: NTR 1345)
Setting
14 Dutch hospitals.
Patients
286 patients with small AAAs between October 2008 and June 2011.
Intervention
Daily dose of 100 mg of doxycycline (n = 144) or placebo (n = 142) for 18 months.
Measurements
The primary outcome measure was aneurysm growth at 18 months, as estimated by repeated single-observer ultrasonography …
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