作者
Weiya Zhang, G Nuki, RW Moskowitz, S Abramson, RD Altman, NK Arden, S Bierma-Zeinstra, KD Brandt, P Croft, M Doherty, M Dougados, M Hochberg, DJ Hunter, K Kwoh, LS Lohmander, P Tugwell
发表日期
2010/4/1
来源
Osteoarthritis and cartilage
卷号
18
期号
4
页码范围
476-499
出版商
WB Saunders
简介
OBJECTIVE
To update evidence for available therapies in the treatment of hip and knee osteoarthritis (OA) and to examine whether research evidence has changed from 31 January 2006 to 31 January 2009.
METHODS
A systematic literature search was undertaken using MEDLINE, EMBASE, CINAHL, AMED, Science Citation Index and the Cochrane Library. The quality of studies was assessed. Effect sizes (ESs) and numbers needed to treat were calculated for efficacy. Relative risks, hazard ratios (HRs) or odds ratios were estimated for side effects. Publication bias and heterogeneity were examined. Sensitivity analysis was undertaken to compare the evidence pooled in different years and different qualities. Cumulative meta-analysis was used to examine the stability of evidence.
RESULTS
Sixty-four systematic reviews, 266 randomised controlled trials (RCTs) and 21 new economic evaluations (EEs) were …
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