作者
Cristina Martínez, Bruno K Rodiño-Janeiro, Beatriz Lobo, Megan L Stanifer, Bernd Klaus, Martin Granzow, Ana M González-Castro, Eloisa Salvo-Romero, Carmen Alonso-Cotoner, Marc Pigrau, Ralph Roeth, Gudrun Rappold, Wolfgang Huber, Rosa González-Silos, Justo Lorenzo, Inés De Torres, Fernando Azpiroz, Steeve Boulant, María Vicario, Beate Niesler, Javier Santos
发表日期
2017/9/1
期刊
Gut
卷号
66
期号
9
页码范围
1537-1538
出版商
BMJ Publishing Group
简介
Objective
Micro-RNAs (miRNAs) play a crucial role in controlling intestinal epithelial barrier function partly by modulating the expression of tight junction (TJ) proteins. We have previously shown differential messenger RNA (mRNA) expression correlated with ultrastructural abnormalities of the epithelial barrier in patients with diarrhoea-predominant IBS (IBS-D). However, the participation of miRNAs in these differential mRNA-associated findings remains to be established. Our aims were (1) to identify miRNAs differentially expressed in the small bowel mucosa of patients with IBS-D and (2) to explore putative target genes specifically involved in epithelial barrier function that are controlled by specific dysregulated IBS-D miRNAs.
Design
Healthy controls and patients meeting Rome III IBS-D criteria were studied. Intestinal tissue samples were analysed to identify potential candidates by: (a) miRNA-mRNA profiling; (b …
学术搜索中的文章
C Martínez, BK Rodiño-Janeiro, B Lobo, ML Stanifer… - Gut, 2017