作者
X Chu, K Korzekwa, R Elsby, K Fenner, A Galetin, Y Lai, Pär Matsson, A Moss, S Nagar, GR Rosania, JPF Bai, JW Polli, Y Sugiyama, KLR Brouwer, International Transporter Consortium
发表日期
2013/7
来源
Clinical Pharmacology & Therapeutics
卷号
94
期号
1
页码范围
126-141
简介
Intracellular concentrations of drugs and metabolites are often important determinants of efficacy, toxicity, and drug interactions. Hepatic drug distribution can be affected by many factors, including physicochemical properties, uptake/efflux transporters, protein binding, organelle sequestration, and metabolism. This white paper highlights determinants of hepatocyte drug/metabolite concentrations and provides an update on model systems, methods, and modeling/simulation approaches used to quantitatively assess hepatocellular concentrations of molecules. The critical scientific gaps and future research directions in this field are discussed.
Clinical Pharmacology & Therapeutics (2013); 94 1, 126–141. doi:10.1038/clpt.2013.78
学术搜索中的文章
X Chu, K Korzekwa, R Elsby, K Fenner, A Galetin, Y Lai… - Clinical Pharmacology & Therapeutics, 2013