作者
Lynn A Sleeper, L LuAnn Minich, Brian M McCrindle, Jennifer S Li, Wilbert Mason, Steven D Colan, Andrew M Atz, Beth F Printz, Annette Baker, Victoria L Vetter, Jane W Newburger, Pediatric Heart Network Investigators
发表日期
2011/5/1
期刊
The Journal of pediatrics
卷号
158
期号
5
页码范围
831-835. e3
出版商
Mosby
简介
OBJECTIVES
To assess the performance of 3 risk scores from Japan that were developed to predict, in children with Kawasaki disease, resistance to intravenous immunoglobulin (IVIG) treatment.
STUDY DESIGN
We used data from a randomized trial of pulsed steroids for primary treatment of Kawasaki disease to assess operating characteristics of the 3 risk scores, and we examined whether steroid therapy lowers the risk of coronary artery abnormalities in patients prospectively classified as IVIG resistant.
RESULTS
For comparability with published cohorts, we analyzed the data of 99 patients who were not treated with steroids (16% IVIG-retreated) and identified male sex, lower albumin level, and higher aspartate aminotransferase level as independent risk factors for IVIG resistance. The Kobayashi score was similar in IVIG-resistant and -responsive patients, yielding a sensitivity of 33% and specificity of 87 …
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LA Sleeper, LLA Minich, BM McCrindle, JS Li… - The Journal of pediatrics, 2011