作者
Victoria A McGuire, Dalya Rosner, Olga Ananieva, Ewan A Ross, Suzanne E Elcombe, Shaista Naqvi, Mirjam MW van den Bosch, Claire E Monk, Tamara Ruiz-Zorrilla Diez, Andrew R Clark, J Simon C Arthur
发表日期
2017/1/1
期刊
Molecular and cellular biology
卷号
37
期号
1
页码范围
e00454-16
出版商
Taylor & Francis
简介
Autocrine or paracrine signaling by beta interferon (IFN-β) is essential for many of the responses of macrophages to pathogen-associated molecular patterns. This feedback loop contributes to pathological responses to infectious agents and is therefore tightly regulated. We demonstrate here that macrophage expression of IFN-β is negatively regulated by mitogen- and stress-activated kinases 1 and 2 (MSK1/2). Lipopolysaccharide (LPS)-induced expression of IFN-β was elevated in both MSK1/2 knockout mice and macrophages. Although MSK1 and -2 promote the expression of the anti-inflammatory cytokine interleukin 10, it did not strongly contribute to the ability of MSKs to regulate IFN-β expression. Instead, MSK1 and -2 inhibit IFN-β expression via the induction of dual-specificity phosphatase 1 (DUSP1), which dephosphorylates and inactivates the mitogen-activated protein kinases p38 and Jun N-terminal …
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