作者
Nicholas R Anthonisen, John E Connett, James P Kiley, Murray D Altose, William C Bailey, A Sonia Buist, William A Conway, Paul L Enright, Richard E Kanner, Peggy O'hara, Gregory R Owens, Paul D Scanlon, Donald P Tashkin, Robert A Wise, MD Altose, AF Connors, S Redline, C Deitz, RF Rakos, WA Conway, A DeHorn, JC Ward, CS Hoppe-Ryan, RL Jentons, JA Reddick, C Sawicki, RA Wise, S Permutt, CS Rand, PD Scanlon, LJ Davis, RD Hurt, RD Miller, DE Williams, GM Caron, GG Lauger, SM Toogood, AS Buist, WM Bjornson, LR Johnson, WC Bailey, CM Brooks, JJ Dolce, DM Higgins, MA Johnson, CD Lorish, BA Martin, DP Tashkin, AH Coulson, H Gong, PI Harber, VC Li, M Roth, MA Nides, MS Simmons, I Zuniga, NR Anthonisen, J Manfreda, RP Murray, SC Rempel-Rossum, JM Stoyko, JE Connett, MO Kjelsberg, MK Cowles, DA Durkin, PL Enright, KJ Kurnow, WW Lee, PG Lindgren, SJ Mongin, P O'hara, HT Voelker, LA Waller, GR Owens, RM Rogers, JJ Johnston, FP Pope, FM Vitale, RE Kanner, MA Rigdon, KC Benton, PM Grant, M Becklake, B Burrows, P Cleary, P Kimbel, L Nett, JK Ockene, RM Senior, GL Snider, W Spitzer, OD Williams, SS Hurd, JP Kiley, MC Wu, SM Ayres, RE Hyatt, BA Mason
发表日期
1994/11/16
期刊
Jama
卷号
272
期号
19
页码范围
1497-1505
出版商
American Medical Association
简介
Objective
—To determine whether a program incorporating smoking intervention and use of an inhaled bronchodilator can slow the rate of decline in forced expiratory volume in 1 second (FEV1) in smokers aged 35 to 60 years who have mild obstructive pulmonary disease.
Design
—Randomized clinical trial. Participants randomized with equal probability to one of the following groups: (1) smoking intervention plus bronchodilator, (2) smoking intervention plus placebo, or (3) no intervention.
Setting
—Ten clinical centers in the United States and Canada.
Participants
—A total of 5887 male and female smokers, aged 35 to 60 years, with spirometric signs of early chronic obstructive pulmonary disease.
Interventions
—Smoking intervention: intensive 12-session smoking cessation program combining behavior modification and use of nicotine gum, with continuing 5-year maintenance program to minimize relapse …
引用总数
1995199619971998199920002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320241837495467979210515013411513413415214198136118113100112988999746255503013