作者
Mathilda TM Mommersteeg, Nigel A Brown, Owen WJ Prall, Corrie de Gier-de Vries, Richard P Harvey, Antoon FM Moorman, Vincent M Christoffels
发表日期
2007/10/26
期刊
Circulation research
卷号
101
期号
9
页码范围
902-909
出版商
Lippincott Williams & Wilkins
简介
The pulmonary vein is sleeved by myocardium, which is a major source of atrial fibrillation and is involved in congenital sinus venosus defects. Little is known about the cellular origin and mechanism of formation of the pulmonary myocardium. We observed a biphasic process of pulmonary myocardium formation in mice. Firstly, a myocardial cell population forms de novo at the connection of the pulmonary vein and the atrium. Genetic labeling revealed that atrial cells do not contribute to this population, indicating it forms by differentiation of pulmonary mesenchymal cells. Secondly, these pulmonary myocardial cells initiate a phase of rapid proliferation and form the pulmonary myocardial sleeve. Pitx2c-deficient mice do not develop a pulmonary myocardial sleeve because they fail to form the initial pulmonary myocardial cells. Genetic-labeling analyses demonstrated that whereas the systemic venous return derives …
引用总数
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MTM Mommersteeg, NA Brown, OWJ Prall… - Circulation research, 2007