作者
Shahrokh F Shariat, Michael J Marberger, Yair Lotan, Marta Sanchez-Carbayo, Craig Zippe, Gerson Lüdecke, Hans Boman, Ihor Sawczuk, Martin G Friedrich, Roberto Casella, Christine Mian, Sanaa Eissa, Hideyuki Akaza, Vincenzo Serretta, Hartwig Huland, Hans Hedelin, Rupesh Raina, Naoto Miyanaga, Arthur I Sagalowsky, Claus G Roehrborn, Pierre I Karakiewicz
发表日期
2006/9/1
期刊
The Journal of urology
卷号
176
期号
3
页码范围
919-926
出版商
No longer published by Elsevier
简介
PURPOSE
We assessed variability in the diagnostic performance of NMP22® for detecting recurrence and progression in patients with Ta, T1, and/or CIS transitional cell carcinoma of the bladder in a large international cohort.
MATERIALS AND METHODS
NMP22® voided urine levels were measured in 2,871 patients who underwent office cystoscopy for monitoring previous stage Ta, T1 and/or CIS transitional cell carcinoma at 12 participating institutions.
RESULTS
Patient characteristics varied considerably among institutions. Overall 1,045 patients (36.4%) had recurrent transitional cell carcinoma (range across institutions 13.6% to 54.3%). Median NMP22® was 5.5 U/ml (range across institutions 2.5 to 18.8). Of the patients 33.5% had grade III tumors (range across institutions 20.6% to 54.0%) and 22.4% had muscle invasive tumors (range across institutions 3.2% to 38.2%). Area under the ROC curve for bladder …
引用总数
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