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In the appearance of the COVID-19 pandemic, many governments had to use the adoption of severe measures to counteract the spread of the infection. Social distancing and lockdown measures have led to a sudden change in people’s habits. People are restricted from traveling and gathering in larger numbers to prevent the COVID-19 pandemic. In that context, the internet plays an important role in supporting e-teaching, remote working, online collaboration, online selling, video streaming, gaming, etc. E-learning in the schools and universities in Viet Nam began at the beginning of school closure after the Tet holiday. E-learning has been carried out simultaneously in all provinces with all educational levels and all available information technology resources. Despite being a low-middle-income country with limited resources, the simultaneous implementation of online learning in Viet Nam has achieved remarkable achievements, contributing to fighting the COVID-19 pandemic in Viet Nam. In this research, we study the effectiveness of chemistry e-teaching and e-learning during the COVID-19 pandemic in northern Viet Nam.