作者
Baha M Sibai, Steve N Caritis, Elizabeth Thom, Mark Klebanoff, Donald McNellis, Laura Rocco, Richard H Paul, Roberto Romero, Frank Witter, Mortimer Rosen, Richard Depp, National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units
发表日期
1993/10/21
期刊
New England Journal of Medicine
卷号
329
期号
17
页码范围
1213-1218
出版商
Massachusetts Medical Society
简介
Background
Although low-dose aspirin has been reported to reduce the incidence of preeclampsia among women at high risk for this complication, its efficacy and safety in healthy, nulliparous pregnant women are not known.
Methods
We studied 3135 normotensive nulliparous women who were 13 to 26 weeks pregnant to determine whether treatment with aspirin reduced the incidence of preeclampsia. Of this group, 1570 women received 60 mg of aspirin per day and 1565 received placebo for the remainder of their pregnancies. We also evaluated the effect of aspirin on maternal and neonatal morbidity.
Results
Of the original group of 3135 women, 2985 (95 percent) were followed throughout pregnancy and the immediate puerperium. The incidence of preeclampsia was lower in the aspirin group (69 of 1485 women [4.6 percent]) than in the placebo group (94 of 1500 women [6.3 percent]) (relative risk, 0.7; 95 …
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BM Sibai, SN Caritis, E Thom, M Klebanoff, D McNellis… - New England Journal of Medicine, 1993