作者
Steve Caritis, Baha Sibai, John Hauth, Marshall D Lindheimer, Mark Klebanoff, Elizabeth Thom, Peter VanDorsten, Mark Landon, Richard Paul, Menachem Miodovnik, Paul Meis, Gary Thurnau, Sidney Bottoms, Donald McNellis, James M Roberts, National Institute of Child Health Human Development Network of Maternal–Fetal Medicine Units
发表日期
1998/3/12
期刊
New England Journal of Medicine
卷号
338
期号
11
页码范围
701-705
出版商
Massachusetts Medical Society
简介
Background
Whether low-dose aspirin prevents preeclampsia is unclear. It is not recommended as prophylaxis in women at low risk for preeclampsia but may reduce the incidence of the disease in women at high risk.
Methods
We conducted a double-blind, randomized, placebo-controlled trial in four groups of pregnant women at high risk for preeclampsia, including 471 women with pregestational insulin-treated diabetes mellitus, 774 women with chronic hypertension, 688 women with multifetal gestations, and 606 women who had had preeclampsia during a previous pregnancy. The women were enrolled between gestational weeks 13 and 26 and received either 60 mg of aspirin or placebo daily.
Results
Outcome data were obtained on all but 36 of the 2539 women who entered the study. The incidence of preeclampsia was similar in the 1254 women in the aspirin group and the 1249 women in the placebo …
引用总数
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