作者
Baha M Sibai, Marshall Lindheimer, John Hauth, Steve Caritis, Peter VanDorsten, Mark Klebanoff, Cora MacPherson, Mark Landon, Menachem Miodovnik, Richard Paul, Paul Meis, Mitchell Dombrowski, Gary Thurnau, James Roberts, Donald McNellis
发表日期
1998/9/3
期刊
New England Journal of Medicine
卷号
339
期号
10
页码范围
667-671
出版商
Massachusetts Medical Society
简介
Background
Women with chronic hypertension who become pregnant have an increased risk of preeclampsia and adverse neonatal outcomes. However, within this group, the risk factors for these adverse events are not known.
Methods
We analyzed data on outcomes for 763 women with chronic hypertension enrolled in a multicenter trial of low-dose aspirin for the prevention of preeclampsia. Preeclampsia was defined as new-onset proteinuria (urinary protein excretion, ≥300 mg per 24 hours) in the 682 women without proteinuria at base line. It was defined according to strict clinical criteria in the 81 women who had proteinuria at base line. The end points were maternal and neonatal outcomes.
Results
Among the 763 women, 193 (25 percent) had preeclampsia. The frequency of preeclampsia was not affected by the presence of proteinuria at base line (27 percent among women with proteinuria, vs. 25 …
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BM Sibai, M Lindheimer, J Hauth, S Caritis… - New England Journal of Medicine, 1998