作者
Paul J Meis, Mark Klebanoff, Elizabeth Thom, Mitchell P Dombrowski, Baha Sibai, Atef H Moawad, Catherine Y Spong, John C Hauth, Menachem Miodovnik, Michael W Varner, Kenneth J Leveno, Steve N Caritis, Jay D Iams, Ronald J Wapner, Deborah Conway, Mary J O'Sullivan, Marshall Carpenter, Brian Mercer, Susan M Ramin, John M Thorp, Alan M Peaceman, Steven Gabbe
发表日期
2003/6/12
期刊
New England Journal of Medicine
卷号
348
期号
24
页码范围
2379-2385
出版商
Massachusetts Medical Society
简介
Background
Women who have had a spontaneous preterm delivery are at greatly increased risk for preterm delivery in subsequent pregnancies. The results of several small trials have suggested that 17 alpha-hydroxyprogesterone caproate (17P) may reduce the risk of preterm delivery.
Methods
We conducted a double-blind, placebo-controlled trial involving pregnant women with a documented history of spontaneous preterm delivery. Women were enrolled at 19 clinical centers at 16 to 20 weeks of gestation and randomly assigned by a central data center, in a 2:1 ratio, to receive either weekly injections of 250 mg of 17P or weekly injections of an inert oil placebo; injections were continued until delivery or to 36 weeks of gestation. The primary outcome was preterm delivery before 37 weeks of gestation. Analysis was …
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PJ Meis, M Klebanoff, E Thom, MP Dombrowski… - New England Journal of Medicine, 2003