作者
Dennis Van der Meer, Jaroslav Rokicki, Tobias Kaufmann, Aldo Córdova-Palomera, Torgeir Moberget, Dag Alnæs, Francesco Bettella, Oleksandr Frei, Nhat Trung Doan, Ida E Sønderby, Olav B Smeland, Ingrid Agartz, Alessandro Bertolino, Janita Bralten, Christine L Brandt, Jan K Buitelaar, Srdjan Djurovic, Marjolein van Donkelaar, Erlend S Dørum, Thomas Espeseth, Stephen V Faraone, Guillén Fernández, Simon E Fisher, Barbara Franke, Beathe Haatveit, Catharina A Hartman, Pieter J Hoekstra, Asta K Håberg, Erik G Jönsson, Knut K Kolskår, Stephanie Le Hellard, Martina J Lund, Astri J Lundervold, Arvid Lundervold, Ingrid Melle, Jennifer Monereo Sánchez, Linn C Norbom, Jan E Nordvik, Lars Nyberg, Jaap Oosterlaan, Marco Papalino, Andreas Papassotiropoulos, Giulio Pergola, Dominique JF De Quervain, Geneviève Richard, Anne-Marthe Sanders, Pierluigi Selvaggi, Elena Shumskaya, Vidar M Steen, Siren Tønnesen, Kristine M Ulrichsen, Marcel P Zwiers, Ole A Andreassen, Lars T Westlye, Alzheimer’s Disease Neuroimaging Initiative, Pediatric Imaging, Neurocognition and Genetics Study
发表日期
2020/11
期刊
Molecular psychiatry
卷号
25
期号
11
页码范围
3053-3065
出版商
Nature Publishing Group UK
简介
The hippocampus is a heterogeneous structure, comprising histologically distinguishable subfields. These subfields are differentially involved in memory consolidation, spatial navigation and pattern separation, complex functions often impaired in individuals with brain disorders characterized by reduced hippocampal volume, including Alzheimer’s disease (AD) and schizophrenia. Given the structural and functional heterogeneity of the hippocampal formation, we sought to characterize the subfields’ genetic architecture. T1-weighted brain scans (n = 21,297, 16 cohorts) were processed with the hippocampal subfields algorithm in FreeSurfer v6.0. We ran a genome-wide association analysis on each subfield, co-varying for whole hippocampal volume. We further calculated the single-nucleotide polymorphism (SNP)-based heritability of 12 subfields, as well as their genetic correlation with each other, with other …
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D Van der Meer, J Rokicki, T Kaufmann… - Molecular psychiatry, 2020