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To the Editor: The frequency of methamphetamine use has alarmingly increased in Iran, as in many other countries in recent years. 1 The most recent survey on drug abuse in Iran, performed a couple of years ago, showed that only a minority of the Iranian substance abusers (3.6%) used methamphetamine. 2 However, in the past 2 years and with the local production of methamphetamine, its price has dropped to less than one-fifth its former price. Methamphetamine use has increased several-fold in that time, and current nonofficial estimates suggest that methamphetamine is currently the second or third most widely used illicit substance in Iran, which means its use is in a real epidemic state. Moreover, many of the patients who abstain from opioids, including the patient described in the present case, turn to methamphetamine as an assumed “non-addicting” substitute. As a result, methamphetamine-induced …