作者
Anna Schritz, Nassera Aouali, Aurélie Fischer, Coralie Dessenne, Roisin Adams, Guy Berchem, Laetitia Huiart, Susanne Schmitz
发表日期
2021/1/1
来源
Neuro-Oncology Advances
卷号
3
期号
1
页码范围
vdab052
出版商
Oxford University Press
简介
Background
Despite advances in the treatment of cancers over the last years, treatment options for patients with recurrent glioblastoma (rGBM) remain limited with poor outcomes. Many regimens have been investigated in clinical trials; however, there is a lack of knowledge on comparative effectiveness. The aim of this systematic review is to provide an overview of existing treatment strategies and to estimate the relative efficacy of these regimens in terms of progression-free survival (PFS) and overall survival (OS).
Methods
We conducted a systematic review to identify randomized controlled trials (RCTs) investigating any treatment regimen in adult patients suffering from rGBM. Connected studies reporting at least one of our primary outcomes were included in a Bayesian network meta-analysis (NMA) estimating relative treatment effects.
Results
Forty RCTs …
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A Schritz, N Aouali, A Fischer, C Dessenne, R Adams… - Neuro-Oncology Advances, 2021