作者
James D Douketis, Alex C Spyropoulos, Joanne Duncan, Marc Carrier, Gregoire Le Gal, Alfonso J Tafur, Thomas Vanassche, Peter Verhamme, Sudeep Shivakumar, Peter L Gross, Agnes YY Lee, Erik Yeo, Susan Solymoss, Jeannine Kassis, Geneviève Le Templier, Stephen Kowalski, Mark Blostein, Vinay Shah, Elizabeth MacKay, Cynthia Wu, Nathan P Clark, Shannon M Bates, Frederick A Spencer, Eleni Arnaoutoglou, Michiel Coppens, Donald M Arnold, Joseph A Caprini, Na Li, Karen A Moffat, Summer Syed, Sam Schulman
发表日期
2019/11/1
期刊
JAMA internal medicine
卷号
179
期号
11
页码范围
1469-1478
出版商
American Medical Association
简介
Importance
Patients with atrial fibrillation (AF) who use a direct oral anticoagulant (DOAC) and request elective surgery or procedure present a common clinical situation yet perioperative management is uncertain.
Objective
To investigate the safety of a standardized perioperative DOAC management strategy.
Design, Setting, and Participants
The Perioperative Anticoagulation Use for Surgery Evaluation (PAUSE) cohort study conducted at 23 clinical centers in Canada, the United States, and Europe enrolled and screened patients from August 1, 2014, through July 31, 2018. Participants (n = 3007) had AF; were 18 years of age or older; were long-term users of apixaban, dabigatran etexilate, or rivaroxaban; were scheduled for an elective surgery or procedure; and could adhere to the DOAC therapy interruption protocol.
Interventions
A simple standardized perioperative DOAC therapy interruption and resumption …
学术搜索中的文章
JD Douketis, AC Spyropoulos, J Duncan, M Carrier… - JAMA internal medicine, 2019