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Tumor pH is physiologically important since it influences a number of processes relevant to tumorigenesis and therapy. Hence, knowledge of localized pH within tumors would contribute to understanding these processes. The destructiveness, poor spatial resolution, and poor signal‐to‐noise ratio (SNR) of current technologies (e.g., microelectrodes, ³¹P magnetic resonance spectroscopy) have limited such studies. An extrinsic chemical extracellular pH (pH_e) probe is described that is used in combination with ¹H magnetic resonance spectroscopic imaging to yield pH_e maps with a spatial resolution of 1 × 1 × 4 mm³. The principle of the technique is demonstrated on a phantom. Further data are shown to demonstrate its application in vivo, and results agree with previously reported pH values. The accuracy of the reported pH measurements is <0.1 pH units, as derived from a detailed analysis of the errors …