作者
Barbara Cambiaghi, Francesco Vasques, Onnen Mörer, Christian Ritter, Tommaso Mauri, Nils Kunze-Szikszay, Karin Holke, Francesca Collino, Giorgia Maiolo, Francesca Rapetti, Elias Schulze-Kalthoff, Tommaso Tonetti, Günter Hahn, Michael Quintel, Luciano Gattinoni
发表日期
2017/12
期刊
Intensive care medicine experimental
卷号
5
页码范围
1-11
出版商
Springer International Publishing
简介
Background
Severe hypoperfusion can cause lung damage. We studied the effects of regional perfusion block in normal lungs and in the lungs that had been conditioned by lavage with 500 ml saline and high V T (20 ml kg−1) ventilation.
Methods
Nineteen pigs (61.2 ± 2.5 kg) were randomized to five groups: controls (n = 3), the right lower lobe block alone (n = 3), lavage and high V T (n = 4), lung lavage, and high V T plus perfusion block of the right (n = 5) or left (n = 4) lower lobe. Gas exchange, respiratory mechanics, and hemodynamics were measured hourly. After an 8-h observation period, CT scans were obtained at 0 and 15 cmH2O airway pressure.
Results
Perfusion block did not damage healthy lungs. In conditioned lungs, the left perfusion block caused more edema …
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B Cambiaghi, F Vasques, O Mörer, C Ritter, T Mauri… - Intensive care medicine experimental, 2017