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There are high number of studies about the relationship between inflammation and tinnitus. The aim of this study was to evaluate the prognostic importance of the use of the neutrophil-lymphocyte ratio (NLR), the platelet lymphocyte ratio (PLR), and the mean platelet volume (MPV) in patients with tinnitus. This prospective study included 74 patients and 65 healthy control group. The severity of the tinnitus was classified using the Tinnitus Handicap Index (THI). The neutrophil and lymphocyte counts, NLR, PLR and MPV values were recorded and compared between the groups. MPV, and MCV median values were determined statistically significantly higher in the patient group than in the control group (p:0.001, p:0.000). No statistically significant difference was determined between the groups in respect of the NLR and PLR (p>0.05). The mean THI score was calculated as 51.5±21.1 (range, 12.0- 90.0). No statistically significant correlations were determined between the THI and NLR and PLR (r:0.03, p:0.75, and r:0.04, p:0.70). The MPV and MCV values were higher in tinnitus patients than in the control group. However, NLR and PLR were not determined to have any statistically significant relationship with tinnitus or the THI scores.