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2.8 A 88: Willian et al. and/or a pharmaceutically-acceptable salt, hydrate, Solvate, 4.74 s. 160 A 5, 1988 Bennion et al. tautomer, optical isomer, E-isomer, Z-isomer, or combination 4.937, 843 A 5, 1990 Teitz thereof, wherein the remaining substituents are described 4,977,051 A 12/1990 Ohno et al. herein; and a composition comprising the thiosemicarbazone 4,978,670 A 12/1990 Rector et al. and/or the semicarbazone. The invention also relates to a 4,985,433 A 1/1991 Secrist, III et al. method of administration of a thiocarbazone and/or a semi