作者
Vinod Tiwari, Michael Anderson, Fei Yang, Vineeta Tiwari, Qin Zheng, Shao-Qiu He, Tong Zhang, Bin Shu, Xueming Chen, Shaness A Grenald, Kimberly E Stephens, Zhiyong Chen, Xinzhong Dong, Srinivasa N Raja, Yun Guan
发表日期
2018/6/1
期刊
Anesthesiology
卷号
128
期号
6
页码范围
1220-1236
简介
Background
Ongoing neuropathic pain is difficult to treat. The authors examined whether dermorphin [D-Arg2, Lys4] (1–4) amide, a peripherally acting µ-opioid receptor agonist, attenuates ongoing pain-associated manifestations after nerve injury in rats and mice.
Methods
Using conditioned place preference assay, the authors tested whether animals show a preference to the environment associated with drug treatment. Wide-dynamic range and dorsal root ganglion neuronal activities were measured by electrophysiology recording and calcium imaging.
Results
Nerve-injured animals stayed longer in dermorphin [D-Arg2, Lys4] (1–4) amide–paired chamber after conditioning than during preconditioning (rats: 402.4 ± 61.3 vs. 322.1 ± 45.0 s, 10 mg/kg, n = 9, P = 0.009; mice: 437.8 ± 59.4 vs. 351.3 ± 95.9 s, 2 mg/kg, n = 8, P = 0.047). Topical …
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V Tiwari, M Anderson, F Yang, V Tiwari, Q Zheng… - Anesthesiology, 2018