作者
Shao-Qiu He, Zhe Li, Yu-Xia Chu, Liang Han, Qian Xu, Man Li, Fei Yang, Qin Liu, Zongxiang Tang, Yun Wang, Niyada Hin, Takashi Tsukamoto, Barbara Slusher, Vinod Tiwari, Ronen Shechter, Feng Wei, Srinivasa N Raja, Xinzhong Dong, Yun Guan
发表日期
2014/3/1
期刊
Pain
卷号
155
期号
3
页码范围
534-544
出版商
LWW
简介
Our research suggests that MrgC agonism at spinal sites constitutes a novel pain inhibitory mechanism in rodent models of neuropathic pain.
ABSTRACT Chronic neuropathic pain is often refractory to current pharmacotherapies. The rodent Mas-related G-protein-coupled receptor subtype C (MrgC) shares substantial homogeneity with its human homologue, MrgX1, and is located specifically in small-diameter dorsal root ganglion neurons. However, evidence regarding the role of MrgC in chronic pain conditions has been disparate and inconsistent. Accordingly, the therapeutic value of MrgX1 as a target for pain treatment in humans remains uncertain. Here, we found that intrathecal injection of BAM8-22 (a 15-amino acid peptide MrgC agonist) and JHU58 (a novel dipeptide MrgC agonist) inhibited both mechanical and heat hypersensitivity in rats after an L5 spinal nerve ligation (SNL). Intrathecal JHU58-induced …
学术搜索中的文章
SQ He, Z Li, YX Chu, L Han, Q Xu, M Li, F Yang, Q Liu… - Pain, 2014