作者
Yu N Antonenko, AV Avetisyan, LE Bakeeva, BV Chernyak, VA Chertkov, LV Domnina, O Yu Ivanova, DS Izyumov, LS Khailova, SS Klishin, GA Korshunova, KG Lyamzaev, MS Muntyan, OK Nepryakhina, AA Pashkovskaya, O Yu Pletjushkina, AV Pustovidko, VA Roginsky, TI Rokitskaya, EK Ruuge, VB Saprunova, II Severina, RA Simonyan, IV Skulachev, MV Skulachev, NV Sumbatyan, IV Sviryaeva, VN Tashlitsky, JM Vassiliev, M Yu Vyssokikh, LS Yaguzhinsky, AA Zamyatnin, VP Skulachev
发表日期
2008/12
期刊
Biochemistry (Moscow)
卷号
73
页码范围
1273-1287
出版商
SP MAIK Nauka/Interperiodica
简介
Synthesis of cationic plastoquinone derivatives (SkQs) containing positively charged phosphonium or rhodamine moieties connected to plastoquinone by decane or pentane linkers is described. It is shown that SkQs (i) easily penetrate through planar, mitochondrial, and outer cell membranes, (ii) at low (nanomolar) concentrations, posses strong antioxidant activity in aqueous solution, BLM, lipid micelles, liposomes, isolated mitochondria, and cells, (iii) at higher (micromolar) concentrations, show pronounced prooxidant activity, the “window” between anti- and prooxidant concentrations being very much larger than for MitoQ, a cationic ubiquinone derivative showing very much lower antioxidant activity and higher prooxidant activity, (iv) are reduced by the respiratory chain to SkQH2, the rate of oxidation of SkQH2 being lower than the rate of SkQ reduction, and (v) prevent oxidation of mitochondrial …
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YN Antonenko, AV Avetisyan, LE Bakeeva… - Biochemistry (Moscow), 2008